GE Healthcare organized the 10th GE Breast Academy in Lisbon on November 3 and 4, 2022, which was attended by more than 1000 international radiologists. The latest developments in breast imaging, such as risk-adapted breast cancer screening based on genetic scores and biopsies using contrast-enhanced mammography, were presented and discussed in detail. Prof. Priv.-Doz. Dr. Ramona Woitek presented her work in hybrid imaging using PET-MRI and tracers such as 18F-FDG, 18F-FMISO and 18F-FLT to visualize glucose metabolism, hypoxia and cell proliferation in breast cancer. She also showed the world's first results of her study with the University of Cambridge on breast imaging using hyper-PET MRI, where proton MRI, hyperpolarized 13C MRI, and dynamic 18F-FDG PET are combined in a single study to draw a very detailed picture of both glucose uptake and metabolism within a tumor. Simultaneously, tumor vascularization and cell density are imaged. There are high expectations for this very complex one-stop-shop technique, especially for the very early assessment of therapy response in patients undergoing chemotherapy.